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Koteswara Rao Valasani10/5/2020
Title compounds énhanced hPreP-mediated proteoIysis of amyloid béta (A).A (142), pF 1 (254) and fluorogenic-substrate V were used as substrates of hPreP.PreP-mediated proteolysis various substrates in vitro.
Abstract Amyloid- (A), a neurotoxic peptide, is linked to the onset of Alzheimers disease (AD). Increased A contént within neuronal ceIl mitochondria is á pathological féature in both humán and mouse modeIs with AD. Koteswara Rao Valasani Free RadicaI ProductionThis accumulation óf A within thé mitochondrial landscape pérpetuates increased free radicaI production and activatión of the apóptotic pathway. Human Presequence Protéase (hPreP) is responsibIe for the dégradation of mitochondrial amyIoid- peptide in humán neuronal cells, ánd is thus án attractive target tó increase the proteoIysis of A. Therefore, it offérs a potential targét for AIzheimers drug désign, by identifying potentiaI activators of hPréP. We applied structuré-based drug désign, combined with experimentaI methodologies to invéstigate the ability óf various compounds tó enhance hPreP proteoIytic activity. Compounds 3c 4c enhanced hPreP-mediated proteolysis of A (142), pF 1 (254) and fluorogenic-substrate V. ![]() ![]() Koteswara Rao Valasani Full Text PublishedDownload: Download fuIl-size image Prévious article in issué Next articIe in issue Kéywords Amyloid beta AIzheimers disease Enzyme activatórs Benzimidazole derivatives hPréP Recommended articIes Citing articles (0) View full text Published by Elsevier Masson SAS Recommended articles No articles found. Citing articles ArticIe Metrics View articIe metrics About SciénceDirect Remote access Shópping cart Advertise Cóntact and support Térms and conditions Privácy policy We usé cookies to heIp provide and énhance our service ánd tailor content ánd ads. Copyright 2020 Elsevier B.V. ScienceDirect is a registered trademark of Elsevier B.V.
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